Article Navigation
- < Previous
- Next >
Journal Article
Get access
, Sandro Giannini, M.D. National Research Council, Center for Aging Studies of Padova, Padova, Italy Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Angela D'Angelo Division of Nephrology, University of Padova, Padova, Italy Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Martino Nobile Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Gianni Carraro Division of Nephrology, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Paolo Rigotti Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Fatima Silva‐Netto Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Silvia Pavan Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Francesco Marchini Division of Nephrology, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Martina Zaninotto Department of Laboratory Medicine, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Luca Dalle Carbonare National Research Council, Center for Aging Studies of Padova, Padova, Italy Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic
, Leonardo Sartori National Research Council, Center for Aging Studies of Padova, Padova, Italy Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic Gaetano Crepaldi National Research Council, Center for Aging Studies of Padova, Padova, Italy Department of Medical and Surgical Sciences, University of Padova, Padova, Italy Search for other works by this author on: Oxford Academic
Journal of Bone and Mineral Research, Volume 17, Issue 10, 1 October 2002, Pages 1768–1773, https://doi.org/10.1359/jbmr.2002.17.10.1768
Published:
02 December 2009
Article history
Received:
21 December 2001
Revision received:
02 April 2002
Accepted:
26 April 2002
Published:
02 December 2009
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Sandro Giannini, Angela D'Angelo, Martino Nobile, Gianni Carraro, Paolo Rigotti, Fatima Silva‐Netto, Silvia Pavan, Francesco Marchini, Martina Zaninotto, Luca Dalle Carbonare, Leonardo Sartori, Gaetano Crepaldi, The Effects of Vitamin D Receptor Polymorphism on Secondary Hyperparathyroidism and Bone Density After Renal Transplantation, Journal of Bone and Mineral Research, Volume 17, Issue 10, 1 October 2002, Pages 1768–1773, https://doi.org/10.1359/jbmr.2002.17.10.1768
Close
Abstract
Immunosuppresive treatment and secondary hyperparathyroidism (SHPT) are considered among the most important pathogenetic factors for postrenal transplant bone disease. The aim of this study was to investigate the relationships among vitamin D receptor (VDR) gene polymorphism, parathyroid hormone (PTH) levels, and bone density in renal transplant recipients. We enrolled 69 patients (47 men and 22 women; mean age, 47 ± 11 years) who had undergone kidney transplantation 51 ± 5 months before. All patients underwent an evaluation of the main biochemical parameters of bone metabolism as well as bone densitometry. VDR alleles were typed by a polymerase chain reaction (PCR) assay based on a polymorphic BsmI restriction site. When the patients were categorized according to the VDR genotype (BB, Bb, and bb), serum creatinine, and the cumulative doses of immunosuppressive drugs were similar across the groups. PTH levels higher than 80 pg/ml were found in 53.6% of the patients, with the highest values being detected in the bb VDR genotype (p < 0.05). PTH was significantly correlated to urinary type I collagen cross‐linked N‐telopeptide (NTx) values. Bone density was low in the whole population; however, spinal bone density was lower in the bb subgroup (p < 0.02). In the whole population, only PTH (p < 0.05) and body mass index (BMI; p < 0.01) were independent predictors of spinal bone density. When grouping the patients by the VDR gene polymorphism, only PTH continued to be an independent predictor of spinal bone density in the bb allele subgroup (R2 adj. = 0.17). We can conclude that the VDR genotype polymorphism affects bone density of renal transplant recipients via its effects on the severity of SHPT.
bone density, bone turnover, renal transplantation, secondary hyperparathyroidism, vitamin D receptor
Copyright © 2002 ASBMR
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Issue Section:
Research‐Articles
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
-
American Society for Bone and Mineral Research members
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
The Effects of Vitamin D Receptor Polymorphism on Secondary Hyperparathyroidism and Bone Density After Renal Transplantation* - 24 Hours access
EUR €46.00
GBP £40.00
USD $49.00
Rental
This article is also available for rental through DeepDyve.
Advertisem*nt
Email alerts
Article activity alert
Advance article alerts
New issue alert
Receive exclusive offers and updates from Oxford Academic
Email alerts
Advance article alerts
New issue alert
Receive exclusive offers and updates from Oxford Academic
Related articles in
- Web of Science
- Google Scholar
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
More from Oxford Academic
Clinical Medicine
Endocrinology and Diabetes
Medicine and Health
Books
Journals
Advertisem*nt
